Name:Ling-Li Dong

Dean of Department of Rheumatology, TJH;
Associate Professor, Associate Chief Physician of Department of Rheumatology, TJH;
Young and Middle-aged Committee Member of the Chinese Rheumatology Association;
Committee Member of the Rheumatology Association of Hubei Province;
Vice Chairman of the Never electrophysiology and Electroencephalogram Association of Wuhan.

Educational Background

2003-2007  Ph.D. Kanazawa Medical University, Japan;
1996-1999  Master Degree  Tongji Medical College; Huazhong University of Science and Technology, China;
1991-1996  M.D. Tongji Medical College, Huazhong University of Science and Technology, China.


Pathogenesis and immune regulation of autoimmune diseases.

Key Projects Involved

2008      NSFC No. 30840006      RMB 80,000;
2009-2012  NSFC No. 30972706     RMB 280,000;
2013-2016  NSFC No. 31270965     RMB 800,000.
(NSFC: National Natural Science Foundation of China) 

Honors & Awards

2007-2008  Reward of Uehara Memorial Foundation;
2012 April 2012 JCR travel awards.


1.Dong L, Watanabe K, Iton M et al.CD4+T-cell dysfunctions through impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin sythase1-knockout mice. Int Immunol. 2012 May;24(5):327-37. Epub 2012 Feb 17.
2.Dong L, Hu S, Chen F, Lei X, Tu W, Yu Y, Yang L, Sun W, Yamaguchi T, Masaki Y, Umehara H. Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in Systemic Lupus Erythematosus patients. J Biomed Biotechnol. 2010;2010:569053. Epub 2010 Jun 30.
3.Masaki Y, Dong L*, Kurose N, Kitagawa K, Morikawa Y, Yamamoto M, Takahashi H, Shinomura Y, Imai K, Saeki T, Azumi A, Nakada S, Sugiyama E, Matsui S, Origuchi T, Nishiyama S, Nishimori I, Nojima T, Yamada K, Kawano M, Zen Y, Kaneko M, Miyazaki K, Tsubota K, Eguchi K, Tomoda K, Sawaki T, Kawanami T, Tanaka M, Fukushima T, Sugai S, Umehara H. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis. 2009 Aug;68(8):1310-5.
4.Masaki Y, Dong L, Nakajima A, Iwao H, Miki M, Kurose N, Kinoshita E, Nojima T, Sawaki T, Kawanami T, Tanaka M, Shimoyama K, Kim C, Fukutoku M, Kawabata H, Fukushima T, Hirose Y, Takiguchi T, Konda S, Sugai S, Umehara H. Intravascular large B cell lymphoma: proposed of the strategy for early diagnosis and treatment of patients with rapid deteriorating condition. Int J Hematol. 2009 Jun;89(5):600-10.
5.Jin ZX, Huang CR, Dong L, Goda S, Kawanami T, Sawaki T, Sakai T, Tong XP, Masaki Y, Fukushima T, Tanaka M, Mimori T, Tojo H, Bloom ET, Okazaki T, Umehara H. Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells. Int Immunol. 2008 Nov;20(11):1427-37.
6.Fukushima T, Dong L*, Sakai T, Sawaki T, Miki M, Tanaka M, Masaki Y, Hirose Y, Kuwana M, Umehara H. Successful treatment of amegakaryocytic thrombocytopenia with anti-CD20 antibody (rituximab) in a patient with systemic lupus erythematosus. Lupus. 2008;17(3):210-4.
7.Dong L, Chandrasekaran V, Zhou W, Tsai HM. Evolution of ADAMTS13 antibodies in a fatal case of thrombotic thrombocytopenic purpura. Am J Hematol. 2008 Oct;83(10):815-7.
8.Dong L, Masaki Y, Takegami T, Jin ZX, Huang CR, Fukushima T, Sawaki T, Kawanami T, Saeki T, Kitagawa K, Sugai S, Okazaki T, Hirose Y, Umehara H. Clonality analysis of lymphoproliferative disorders in patients with Sjögren's syndrome. Clin Exp Immunol. 2007 Nov;150(2):279-84.
9.Dong L, Masaki Y, Takegami T, Kawanami T, Itoh K, Jin ZX, Huang CR, Tong XP, Fukushima T, Tanaka M, Sawaki T, Sakai T, Sugai S, Okazaki T, Hirose Y, Umehara H. Cloning and expression of two human recombinant monoclonal Fab fragments specific for EBV viral capsid antigen. Int Immunol. 2007 Mar;19(3):331-6.
10.Dong L, Masaki Y, Tanaka M, Fukushima T, Okazaki T, Umehara H. Sjögren’s syndrome and lymphoma development. Curr Immunol Rev. 2007;3,289-296.
11.Sun W, Dong L*, Kaneyama K, Takegami T, Segami N. Bacterial diversity in synovial fluids of patients with TMD determined by cloning and sequencing analysis of the 16S ribosomal RNA gene. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(5):556-71. 
12.Umehara H, Tanaka M, Sawaki T, Jin ZX, Huang CR, Dong L, Kawanami T, Karasawa H, Masaki Y, Fukushima T, Hirose Y, Okazaki T. Fractalkine in rheumatoid arthritis and allied conditions. Mod Rheumatol. 2006;16(3):124-30. Review.
13.Sugai S, Masaki Y, Dong L. Lymphoproliferative disorders in patients with Sjögren's syndrome. Autoimmun Rev. 2004 Jun;3 Suppl 1:S67-9. Review.
14.Zhou W, Dong L, Ginsburg D, Bouhassira EE, Tsai HM. Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy? J Biol Chem. 2005 Dec 2;280(48):39934-41.
15.Dong L, Sun H, Liu W, Xu H, Tao D. Expression of adherent molecule and cyclin by ligustrazine in bone marrow of mice with immune-induced aplastic anemia. J Tongji Med Univ. 1999;19(1):31-3.
*The first two authors equally contributed to this paper.