Deans

Name:Gang Xu

Dean of Division of Nephrology, Tongji Hospital;
Professor; Chief Physician; Doctoral Supervisor;
Chairman of Hubei Society of Blood Purification Administration;
Board Member of Hubei medical association of Renal Disease;
Committee Member of Chinese Society of Renal Physician;
Board Member of Chinese Society of Blood Purification Administration;
Chief Editor of Journal of Clinical Nephrology
Editorial Board Member of Chinese Journal of Nephrology;
Editorial Board Member of Chinese Journal of Blood Purification.

Educational Background

2003 Postdoctoral, Department of Biology, University of Iowa, USA
2006 Ph.D & M.D.,Tongji Medical University

Key Projects Involved

1.Project molecular mechanism and intervention study of TGF-beta1 inducing renal fibrosis was the general project supported by The National Natural Science Foundation of China. Number : 30370657. 2004-2006.(Project leader)
2.Program for New Century Excellent Talents in University NCET-04-0712 .2005-2008.(Project Leader)
3.The project mechanism study of relationship between Beta - Catenin tyrosine phosphorylation state and renal fibrosis was supported by Hubei Provincial Natural Science Foundation of China.2007-2009. (Project Leader)
4. Epidemiology investigation and intervention study of chronic kidney disease for Urumqi city residents was supported by the national technological department.2008-2010.(Project Leader)
5.The function and mechanism study of CIP4 splicing variant in transdifferentiation of renal tubular epithelial cell was the general Project supported by The National Natural Science Foundation of China.Number: 30871172.2009-2011.(Project Leader)
6.The function and intervention study of  Sema4C / Erbin heterodimer formation in the process of TGF-beta1 transdifferentiation of renal tubular epithelial cells was the general project supported by The National Natural Science Foundation of China.Number:30971372.2010-2012.(Project Leader)
7. Project of Chinese Ministry of Education Innovation Team was supported by the innovational program of the educational department.
8.The principal of Industry Speciality of The Chinese Ministry of Health prevention and treatment of major diseases.
9. Biomarkers for early diagnosis of peritoneal fibrosis was supported by Baxter Company.
10.Newly formed lymphatic vessels and tertiary lymphoid tissue -new targets to intervent renal fibrosis. Supported by The National Natural Science Foundation of China. Number :81270770.2013-2016.(Project leader)

 

Publication

1. Rui Zeng, Min Han, Yun Luo, Caixia Li, Guangchang Pei, Wenhui Liao,Shoujun Bai, Shuwang Ge, XiaoCheng Liu, Gang Xu(Corresponding). Role of Sema4C in TGF-{beta}1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells.2010 [Epub ahead of print, PMID: 20959347].
2. Huang X, Bai X, Cao Y, Wu J, Huang M, Tang D, Tao S, Zhu T, Liu Y, Yang Y, Zhou X, Zhao Y, Wu M, Wei J, Wang D, Xu G, Wang S, Ma D, Zhou J. Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion. J Exp Med. 2010 Mar 15;207(3):505-20
3. You L, Wu M, Chen Y, Xu G, Wei J, Li Q, Song A, Zhao L, Li S, Han Z, Zhou J, Lu Y, Wang S, Ma D, Meng L. Isolation and characterization of lymphatic endothelial cells from human glossal lymphangioma. Oncol Rep. 2010,23(1):105-111
4. Wu M, Han L, Shi Y, Xu G, Wei J, You L, Chen Y, Zhu T, Li Q, Li S, Meng L, Lu Y, Zhou J, Wang S, Ma D.Development and characterization of a novel method for the analysis of gene expression patterns in lymphatic endothelial cells derived from primary breast tissues. J Cancer Res Clin Oncol. 2010,136(6):863-72.
5. Zou R, Xu G, Liu XC, Han M, Jiang JJ, Huang Q, He Y, Yao Y.PPARgamma agonists inhibit TGF-beta-PKA signaling in glomerulosclerosis. Acta Pharmacol Sin. 2010 Jan;31(1):43-50.
6. Bai SJ,Zhou QD,Zeng R,Li CX,Pei GC,Xu CO,Ge SW,Zhou H,Xu G(corresponding),Liu XC.Study of the Expression and Function of CIP4 in Renal Interstitial Fibrosis. Chinese Journal of Nephrology2010.26(6):453-459.
7. Ge S, Zeng R, Luo Y, Liu L, Wei H, Zhang J, Zhou H, Xu G(Corresponding). Role of protein kinase C in advanced glycation end products-induced epithelial-mesenchymal transition in renal proximal tubular epithelial cells. J Huazhong Univ Sci Technolog Med Sci,2009,29(3):281-5.
8. Zhou QD,Kou P,Zeng R,Bai SJ,Pei GC,Zhang YM, Han M, Liu LL, Xu G(corresponding).Study the Expression and Function of Erbin Protein in Renal Interstitial Fibrosis.Chinese Journal of Nephrology2011.27(5):351-356
9. Rui Zeng, Ying Yao, Min Han, Xiaoqin Zhao, XiaoCheng Liu, Juncheng Wei, Yun Luo, Juan Zhang, Jianfeng Zhou, Shixuan Wang, Ding Ma, Gang Xu(Corresponding). Biliverdin reductase mediates hypoxia-induced EMT via PI3-kinase and Akt. J Am Soc Nephrol 2008,19:380-387.
10. Zou R,Yao Y,Liu XC,Jiang JJ,Huang Q,LIao SJ,Liu L,Ge SW,Xu G(Corresponding)Influence of telmisartan on phenotype alteration in rat mesangial cell through regulating the expression of peroxisome proliferator-activated receptor-γ.Chinese Journal of Nephrology.2008(24)3:208-209
11. Wu M, Xu G(First Author), Xi L, Wei J, Song A, Han Z, Zhou J, Wang S, Zhu T, Zhang A, Lu Y, Ma D. Down-regulation of MT1-MMP expression suppresses tumor cell invasion in metastatic human SW626 ovarian cancer cells. Oncol Rep. 2006 Feb;15(2):501-5. 
12. Han Z, Xu G(First Author), Zhou J, Xing H, Wang S, Wu M, Zhang Y, Lu Y, Ma D. Inhibition of motile and invasive properties of ovarian cancer cells by ASODN against Rho-associated protein kinase. Cell Commun Adhes. 2006 Jan-Apr;12(1-2):59-69.
13. Xu G, Balsamo J, Lilien J.Continual association of cadherin with beta-catenin requires the non-receptor tyrosine kinase Fer.  J Cell Science 2004 Jul.15:136(49): 13-19.
14. Xu G, Craig A, Greer P, Miller M, Anastasiadis P.Z, Lilien J, Balsamo J. The protein tyrosine kinase Fer plays a role in the continuous association of beta-catenin with cadherin. MOL BIOL CELL 14: 2250 suppl. S DEC 2003 
15. Xu G, Shy M, Kamhoz J, Balsamo J.Functional analysis of PKC phosphorylation sites on Myelin Protein Zero. Journal of Clinical Medicine and Pharmacy. 2003 Dec;16(4): 1-7.
16. Xu G, Arregui C, Lilien J, Balsamo J.PTP1B modulates the association of beta-catenin with N-cadherin through binding to an adjacent and partially overlapping target site. J Biol Chem. 2002 Dec 20;277(51):49989-97. 
17. Zhou Q, Zeng R, Xu C, Liu L, Chen L, Kou P, Pei G, Bai S, Zhang Y, Li C, Rong S, Han M, Xu G. Erbin inhibits TGF-β1-induced EMT in renal tubular epithelial cells through an ERK-dependent pathway. J Mol Med (Berl). 2012 May;90(5):563-74. doi: 10.1007/s00109-011-0833-4. Epub 2011 Nov 25.