Professors

Name:Wei Wang

Editor in Chief of Nature Review Neurology (Chinese Edition);
Editor in Chief of Journal of Neuronal Damage and Functional Reconstruction (Chinese);
Member of Society for Neuroscience of China, Member of Medical Society of China;
Associate Director of Medical Society of China .

Educational Background

1979-1982  Hubei National Medical College, P.R. China, Dept. of Clinical Medicine, MD
1987-1990  Chongqing Medical University, P.R. China, Dept. of Neurology, M.Sc
1990-1993  Chongqing Medical University, P.R. China, Dept. of Neurology, Ph.D
1994-1995  Tongji Medical University, P.R. China, Dept. of Neurology, Post  doc Fellow
1999-2001  University of Heirich-Heine, Germany, Dept .of Neurobiology, Ph.D

Research

1. Neuroendocrinology Problems;
2. Pituitary Gland Disorders;
3. Adrenal Tumors.

Key Projects Involved

1. Wang W (PI); 2011-2014; Key Grant of National Natural Science Foundation of China
“The role of atrocyte in the damage and repair of neurovascular unit after ischemia”

2. 973 Program –Wang W (PI); 2006-2011; National Basic Research Program of China
“Determining the Factors involved in the Therapeutic Effect of Acupuncture”

3. Wang W (PI); 2008-2011; Excellent Young Scientist Grant of National Natural Science Foundation of China
“Cell cycle characteristic between astrocytes and neurons under physiological and ischemia conditions”

4. 30230140 –Wang W (PI); 2003-2006; National Natural Science Foundation of China
“The effect of Cell Cycle modulation of astrocyte on its Structure and Function”

5. 30170332 -Wang W (PI); 2002-2004; National Natural Science Foundation of China
“Inhibition cell cycle progression reduces reactive astrogliosis after rat focal cerebral ischemia”

6. 2002-247-Wang W (PI); 2002-2004; Science Foundation of Ministry of Education of China
“Study on the Molecular Mechanism of Cell Cycle Regulation in astrocyte”

7. Key Equipment Grant of Ministry of Public Health of China -Wang W (PI); 2001-2004
“Clinical Determination of Ischemic Penumbra and Effective Treatment of Acute Cerebral Ischemia”

 

Honors & Awards

1999-2001 German Bioscience Fellowship, University of Heirich-Heine, Germany
2004          Excellent Young Scientist Fellowship, Ministry of Education of P. R. China
2009          Changjiang Scholarship, Ministry of Education of China

 

Publication

1. Ding H, Xu Y, Bao X, Wang X, Cui G, Wang W*, Hui R, Wang DW.Confirmation of Genomewide Association Signals in Chinese Han Population Reveals Risk Loci for Ischemic Stroke.Stroke. 2010; 41(1):177-80.
2. Xie M, Yi C, Jia L, Luo X, Xu S, Yu Z, Tang Y, Zhu WH, Du Y, Zhang Q, Dong Q, Zhu WZ, Zhang X, Bu B, Wang W, , Glial Gap junctional communication involvement in hippocampal damage after MCAO, Annals of Neurology, 2011, In press
3. Qu WS, Wang YH, Ma JF, Tian DS, Zhang Q, Pan DJ, Yu ZY, Xie MJ, Wang JP, Wang W*.Galectin-1 attenuates astrogliosis-associated injuries and improves recovery of rats following focal cerebral ischemia. J Neurochem. 2011,116(2):217-26
4. Zhang M, Wang X, Jiang F, Wang W, Vincent I, Bu B* ,Mitotic epitopes are incorporated into age-dependent neurofibrillary tangles in Niemann-Pick disease type C. Brain Pathol. 2010 Mar;20(2):367-77.
5. Liu JL, Tian DS, Li ZW, Qu WS, Zhan Y, Xie MJ, Yu ZY, Wang W*, Wu G.Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo.Brain Res. 2010 Feb 26;1316:101-11
6. Ma J, Yu Z, Qu W, Tang Y, Zhan Y, Ding C, Wang W*, Xie M*.Proliferation and differentiation of neural stem cells are selectively regulated by knockout of cyclin D1, J Mol Neurosci, 2010, Sep;42(1):35-43.
7. Qu WS, Wang YH, Wang JP, Tang YX, Zhang Q, Tian DS, Yu ZY, Xie MJ*, Wang W*.Galectin-1 Enhances Astrocytic BDNF Production and Improves Functional Outcome in Rats Following Ischemia, Neurochem Res, 2010, 35:1716–1724  
8. Wang W*, Bu B, Xie M, Zhang M, Yu Z, Tao D, Neural cell cycle dysregulation and central nervous system diseases, Prog. Neurobiol ,2009, 89,1-17
9. Zhang Q, Chen C, Lü J, Xie M, Pan D, Luo X, Yu Z, Dong Q, Wang W*, Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat , Glia. 2009 Jun;57(8):908-20
10. Tian DS, Liu JL, Xie MJ, Zhan Y, Qu WS, Yu ZY, Tang ZP, Pan DJ, and Wang W*. Tamoxifen attenuates in?ammatory-mediated damage and improves functional outcome after spinal cord injury in rats, J. Neurochem. (2009) 109, 1658–1667
11. Yu Y, Luo X, Ren QG, Yi CJ, Yu ZY, Xie XW, Wang W*. The involvement of upregulation and translocation of phospho-Rb in early neuronal apoptosis following focal cerebral ischemia in rats.Neurochem Res. 2009 Jun;34(6):1113-9.
12. Minjie Xie, Wei Wang, Harold K Kimelberg and Min Zhou*,Oxygen and glucose deprivation-induced changes in astrocyte membrane potential and their underlying mechanisms in acute rat hippocampal slices. Journal of Cerebral Blood Flow & Metabolism. 2008 Mar;28(3):456-67.
13. Huaqiu Zhang, Gary P. Schools, Ting Lei, Wei Wang, Harold K. Kimelberg, Min Zhou, Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. Experimental Neurology. 2008. Jul;212(1):44-52
14. Li Ni, Jiagao Lü, Ling Bo Hou, Jiang Tao Yan, Qiao Fan, Rutai Hui, Katherine Cianflone, Wei Wang*, Dao Wen Wang*. Cystatin C, Associated with Hemorrhagic and Ischemic Stroke, Is a Strong Predictor of the Risk of Cardiovascular Events and Death in Chinese - Graeme Hankey. Stroke, 2007,38,3287-3288. 
15. Zhu Z, Zhang Q, Yu Z, Zhang L, Tian D, Zhu S, Bu B, Xie M, Wang W*. Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. Glia. 2007, 55(5): 546-558.
16. Zhijun Zhang, Gang Chen, Wei Zhou, Aihong Song, Tao Xu, Qingming Luo, Wei Wang, Xiao-song Gu  and Shumin Duan*. Regulated ATP release from astrocytes through lysosome exocytosis. Nature cell biology, 2007, 9(8): 945~957
17. Dai-Shi Tian, Zhi-Yuan Yu, Min-Jie Xie, Bi-Tao Bu, Otto W. Witte, Wei Wang*. Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine. Journal of Neuroscience Research, 2006, 84:1053-1063.
18. Zhang X, Yang M, Xu J, Zhang M, Lang B, Wang W*, Vincent A*. Clinical and serological study of myasthenia gravis in HuBei Province, China, J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):386-90.
19. Wang W, Redecker C*, Bidmon HJ, Witte OW. Delayed neuronal death and damage of GDNF family receptors in CA1 following focal cerebral ischemia. Brain Research, 2004, 1023:92-101.
20. Daishi Tian, Minjie Xie, Zhiyuan Yu, Qiang Zhang, Yihui Wang, Bin Chen, Chen Chen, Wei Wang* . Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Research, 2007,1135:177-185.
21. Dai-shi Tian, Qiang Dong, Deng-ji Pan, Yi He, Zhi-yuan Yu, Min-jie Xie, Wei Wang*. Suppression of microglial proliferation by the cell cycle inhibitor olomoucine attenuates reactive astrogliosis after spinal cord injury in rats. Brain Research, 2007,1154:206~214.
22. Xie Minjie, Wang Wei*, Zhu Zhou, Yu Yongfei. Capillary electrophoresis analysis of hydrogen peroxide induced apoptosis in PC12 cells. Journal of Pharmaceutical and Biomedical Analysis. 2005,39 (5): 853-60.
23. Ying Yu Qing-Guo Ren Chen-Ju Yi Zhi-Yuan Yu Xue-Wei Xie Wei Wang*, The Involvement of Upregulation and Translocation of Phospho- Rb In Early Neuronal Apoptosis Following Focal Cerebral Ischemia In Rats. Neurochem Res, 2009 Jun;34(6):1113-9.
24. Wei Wang*, Christoph Redecker; Zhi-Yuan Yu; Min-Jie Xie; Dai-Shi Tian, Liang Zhang ; Bi-Tao Bu , Otto W. Witte. Rat Focal Cerebral Ischemia induced Astrocyte Proliferation and Delayed Neuronal Death were attenuated by Cyclin-Dependent Kinases Inhibition. Journal of Clinical Neuroscience. 2008 Mar;15(3):278-85.
25. Wang X, Zheng H, Liu C, Zhu C, Wang W, Li Z*. Ciliary Neurotrophic Factor-treated Astrocyte Conditioned Medium Regulates the L-type Calcium Channel Activity in Rat Cortical Neurons. Neurochem Res. 2008.33(5):826-32.
26. Laxi Zhang, Hu Ding, Jiangtao Yan, Rutai Hui, Wei Wang, Grace E. Kissling, Darryl C. Zeldin and Dao Wen Wang*.Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population. Pharmacogenetics and Genomics, 2008, 18(1): 45-51.
27. Zhen HU, Hai Ping XING, Zhou ZHU, Wei WANG, Wen Chao GUAN*. Synthesis of Cystine C60 Derivative and Its Protective Effects on Hydrogen Peroxide-induced Apoptosis in PC12 Cells.  Chin. Chem. Lett. 2007,18(2):145-148. 0.336
28. Zhen Hu, Wenchao Guan*, Wei Wang, Lizhen Huang, Haiping Xing, Zhou Zhu. Protective effect of a novel cystine C60 derivative on hydrogen peroxide-induced apoptosis in rat pheochromocytoma PC12 cells. Chemico-Biological Interactions. 2007,167(2):135-144.
29. Chao Liu, Jiliang Wu, Jun Gu, Zhe Xiong, Fang Wang, Jianzhi Wang, Wei Wang and Jianguo Chen*. Baicalein improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Pharmacology Biochemistry and Behavior. 2007,86(3):423-30
30. Zhe Xiong, Chao Liu, Fang Wang, Cailian Li, Wei Wang*, Jianzhi Wang and Jianguo Chen*. Protective effects of breviscapine on ischemic vascular dementia in rats. Biological & Pharmaceutical Bulletin 2006, 29(9):1880-1885.
31. Zhi-Yuan Yu, Wei Wang, Jean-Marc Fritschy, Otto W. Witte, Christoph Redecker*. Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging. Brian research, 2006, 1099:73~81
32. Zhen Hu, Wenchao Guan*, Wei Wang, Lizhen Huang, Haiping Xing, Zhou Zhu. Synthesis of β-alanine C60 Derivative and Its Protective Effect on Hydrogen Peroxide-induced Apoptosis in Rat Pheochromocytoma Cells. Cell Biology International. 2007,31(8):798-804
33. Redecker C*, Wang W, Fritschy JM, et al. Widespread and long-lasting alterations in GABA(A)-receptor subtypes after focal cortical infarcts in rats: Mediation by NMDA-dependent processes. Journal of Cerebral Blood Flow and Metabolism. 2002, 22:1463-1475.
34. He XH, Wang W, Ruan XZ, et al. Effects of antisense glutamic aciddecarboxylase oligodeoxynucleotide on epileptic rats induced by pentylenetetrazol. Chinese Medical  Journal. 2002, 115(3):425-429.
35. Ding H, Xu Y, Bao X, Wang X, Cui G, Wang W*, Hui R, Wang DW.Confirmation of Genomewide Association Signals in Chinese Han Population Reveals Risk Loci for Ischemic Stroke.Stroke. 2010; 41(1):177-80.
36. Minjie Xie, Chenju Yi, Lintao Jia, Xiang Luo, Shabei Xu, Yizhuan Yu,Yingxin Tang, Wenhao Zhu, Yixing Du, Qiang Zhang, Qiang Dong, Wenzhen Zhu, Xia Zhang, Bitao Bu, Wei Wang*, Glial Gap junctional communication involvement in hippocampal damage after MCAO, Annals of Neurology, 2011, In press
37. Qu WS, Wang YH, Ma JF, Tian DS, Zhang Q, Pan DJ, Yu ZY, Xie MJ, Wang JP, Wang W*.Galectin-1 attenuates astrogliosis-associated injuries and improves recovery of rats following focal cerebral ischemia. J Neurochem. 2011,116(2):217-26
38. Zhang M, Wang X, Jiang F, Wang W, Vincent I, Bu B* ,Mitotic epitopes are incorporated into age-dependent neurofibrillary tangles in Niemann-Pick disease type C. Brain Pathol. 2010 Mar;20(2):367-77.
39. Liu JL, Tian DS, Li ZW, Qu WS, Zhan Y, Xie MJ, Yu ZY, Wang W*, Wu G.Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo.Brain Res. 2010 Feb 26;1316:101-11
40. Ma J, Yu Z, Qu W, Tang Y, Zhan Y, Ding C, Wang W*, Xie M*.Proliferation and differentiation of neural stem cells are selectively regulated by knockout of cyclin D1, J Mol Neurosci, 2010, Sep;42(1):35-43.
41. Qu WS, Wang YH, Wang JP, Tang YX, Zhang Q, Tian DS, Yu ZY, Xie MJ*, Wang W*.Galectin-1 Enhances Astrocytic BDNF Production and Improves Functional Outcome in Rats Following Ischemia, Neurochem Res, 2010, 35:1716–1724  
42. Wang W*, Bu B, Xie M, Zhang M, Yu Z, Tao D, Neural cell cycle dysregulation and central nervous system diseases, Prog. Neurobiol ,2009, 89,1-17
43. Zhang Q, Chen C, Lü J, Xie M, Pan D, Luo X, Yu Z, Dong Q, Wang W*, Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat , Glia. 2009 Jun;57(8):908-20
44. Tian DS, Liu JL, Xie MJ, Zhan Y, Qu WS, Yu ZY, Tang ZP, Pan DJ, and Wang W*. Tamoxifen attenuates in?ammatory-mediated damage and improves functional outcome after spinal cord injury in rats, J. Neurochem. (2009) 109, 1658–1667
45. Yu Y, Luo X, Ren QG, Yi CJ, Yu ZY, Xie XW, Wang W*. The involvement of upregulation and translocation of phospho-Rb in early neuronal apoptosis following focal cerebral ischemia in rats.Neurochem Res. 2009 Jun;34(6):1113-9.
46. Minjie Xie, Wei Wang, Harold K Kimelberg and Min Zhou*,Oxygen and glucose deprivation-induced changes in astrocyte membrane potential and their underlying mechanisms in acute rat hippocampal slices. Journal of Cerebral Blood Flow & Metabolism. 2008 Mar;28(3):456-67.
47. Huaqiu Zhang, Gary P. Schools, Ting Lei, Wei Wang, Harold K. Kimelberg, Min Zhou, Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. Experimental Neurology. 2008. Jul;212(1):44-52
48. Li Ni, Jiagao Lü, Ling Bo Hou, Jiang Tao Yan, Qiao Fan, Rutai Hui, Katherine Cianflone, Wei Wang*, Dao Wen Wang*. Cystatin C, Associated with Hemorrhagic and Ischemic Stroke, Is a Strong Predictor of the Risk of Cardiovascular Events and Death in Chinese - Graeme Hankey. Stroke, 2007,38,3287-3288. 
49. Zhu Z, Zhang Q, Yu Z, Zhang L, Tian D, Zhu S, Bu B, Xie M, Wang W*. Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. Glia. 2007, 55(5): 546-558.
50. Zhijun Zhang, Gang Chen, Wei Zhou, Aihong Song, Tao Xu, Qingming Luo, Wei Wang, Xiao-song Gu  and Shumin Duan*. Regulated ATP release from astrocytes through lysosome exocytosis. Nature cell biology, 2007, 9(8): 945~957
51. Dai-Shi Tian, Zhi-Yuan Yu, Min-Jie Xie, Bi-Tao Bu, Otto W. Witte, Wei Wang*. Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine. Journal of Neuroscience Research, 2006, 84:1053-1063.
52. Zhang X, Yang M, Xu J, Zhang M, Lang B, Wang W*, Vincent A*. Clinical and serological study of myasthenia gravis in HuBei Province, China, J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):386-90.
53. Wang W, Redecker C*, Bidmon HJ, Witte OW. Delayed neuronal death and damage of GDNF family receptors in CA1 following focal cerebral ischemia. Brain Research, 2004, 1023:92-101.
54. Daishi Tian, Minjie Xie, Zhiyuan Yu, Qiang Zhang, Yihui Wang, Bin Chen, Chen Chen, Wei Wang* . Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Research, 2007,1135:177-185.
55. Dai-shi Tian, Qiang Dong, Deng-ji Pan, Yi He, Zhi-yuan Yu, Min-jie Xie, Wei Wang*. Suppression of microglial proliferation by the cell cycle inhibitor olomoucine attenuates reactive astrogliosis after spinal cord injury in rats. Brain Research, 2007,1154:206~214.
56. Xie Minjie, Wang Wei*, Zhu Zhou, Yu Yongfei. Capillary electrophoresis analysis of hydrogen peroxide induced apoptosis in PC12 cells. Journal of Pharmaceutical and Biomedical Analysis. 2005,39 (5): 853-60.
57. Ying Yu Qing-Guo Ren Chen-Ju Yi Zhi-Yuan Yu Xue-Wei Xie Wei Wang*, The Involvement of Upregulation and Translocation of Phospho- Rb In Early Neuronal Apoptosis Following Focal Cerebral Ischemia In Rats. Neurochem Res, 2009 Jun;34(6):1113-9.
58. Wei Wang*, Christoph Redecker; Zhi-Yuan Yu; Min-Jie Xie; Dai-Shi Tian, Liang Zhang ; Bi-Tao Bu , Otto W. Witte. Rat Focal Cerebral Ischemia induced Astrocyte Proliferation and Delayed Neuronal Death were attenuated by Cyclin-Dependent Kinases Inhibition. Journal of Clinical Neuroscience. 2008 Mar;15(3):278-85.
59. Wang X, Zheng H, Liu C, Zhu C, Wang W, Li Z*. Ciliary Neurotrophic Factor-treated Astrocyte Conditioned Medium Regulates the L-type Calcium Channel Activity in Rat Cortical Neurons. Neurochem Res. 2008.33(5):826-32.
60. Laxi Zhang, Hu Ding, Jiangtao Yan, Rutai Hui, Wei Wang, Grace E. Kissling, Darryl C. Zeldin and Dao Wen Wang*.Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population. Pharmacogenetics and Genomics, 2008, 18(1): 45-51.
61. Zhen HU, Hai Ping XING, Zhou ZHU, Wei WANG, Wen Chao GUAN*. Synthesis of Cystine C60 Derivative and Its Protective Effects on Hydrogen Peroxide-induced Apoptosis in PC12 Cells.  Chin. Chem. Lett. 2007,18(2):145-148. 0.336
62. Zhen Hu, Wenchao Guan*, Wei Wang, Lizhen Huang, Haiping Xing, Zhou Zhu. Protective effect of a novel cystine C60 derivative on hydrogen peroxide-induced apoptosis in rat pheochromocytoma PC12 cells. Chemico-Biological Interactions. 2007,167(2):135-144.
63. Chao Liu, Jiliang Wu, Jun Gu, Zhe Xiong, Fang Wang, Jianzhi Wang, Wei Wang and Jianguo Chen*. Baicalein improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Pharmacology Biochemistry and Behavior. 2007,86(3):423-30
64. Zhe Xiong, Chao Liu, Fang Wang, Cailian Li, Wei Wang*, Jianzhi Wang and Jianguo Chen*. Protective effects of breviscapine on ischemic vascular dementia in rats. Biological & Pharmaceutical Bulletin 2006, 29(9):1880-1885.
65. Zhi-Yuan Yu, Wei Wang, Jean-Marc Fritschy, Otto W. Witte, Christoph Redecker*. Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging. Brian research, 2006, 1099:73~81
66. Zhen Hu, Wenchao Guan*, Wei Wang, Lizhen Huang, Haiping Xing, Zhou Zhu. Synthesis of β-alanine C60 Derivative and Its Protective Effect on Hydrogen Peroxide-induced Apoptosis in Rat Pheochromocytoma Cells. Cell Biology International. 2007,31(8):798-804
67. Redecker C*, Wang W, Fritschy JM, et al. Widespread and long-lasting alterations in GABA(A)-receptor subtypes after focal cortical infarcts in rats: Mediation by NMDA-dependent processes. Journal of Cerebral Blood Flow and Metabolism. 2002, 22:1463-1475.
68. He XH, Wang W, Ruan XZ, et al. Effects of antisense glutamic aciddecarboxylase oligodeoxynucleotide on epileptic rats induced by pentylenetetrazol. Chinese Medical  Journal. 2002, 115(3):425-429.